Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
About this item
Full title
Author / Creator
Labrijn, Aran F. , Meesters, Joyce I. , de Goeij, Bart E. C. G. , van den Bremer, Ewald T. J. , Neijssen, Joost , van Kampen, Muriel D. , Strumane, Kristin , Verploegen, Sandra , Kundu, Amitava , Gramer, Michael J. , van Berkel, Patrick H. C. , van de Winkel, Jan G. J. , Schuurman, Janine and Parren, Paul W. H. I.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The promise of bispecific antibodies (bsAbs) to yield more effective therapeutics is well recognized; however, the generation of bsAbs in a practical and cost-effective manner has been a formidable challenge. Here we present a technology for the efficient generation of bsAbs with normal IgG structures that is amenable to both antibody drug discover...
Alternative Titles
Full title
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_110_13_5145
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_110_13_5145
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1220145110
