Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope labeling to monitor the kinetics of fibril formation by human islet amyloid polypeptide (hIAPP or amylin) that is associated with type 2 diabetes. We find that an oligomeric inte...
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Full title
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet
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TN_cdi_pnas_primary_110_48_19285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_110_48_19285
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1314481110
