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Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repe...

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repe...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_33_12025

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5

About this item

Full title

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12025-12030

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Interferon (IFN) responses play key roles in cellular defense against pathogens. Highly expressed IFN-induced proteins with tetratricopeptide repeats (IFITs) are proposed to function as RNA binding proteins, but the RNA binding and discrimination specificities of IFIT proteins remain unclear. Here we show that human IFIT5 has comparable affinity fo...

Alternative Titles

Full title

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_111_33_12025

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_33_12025

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1412842111

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