new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Significance Microtubules are dynamic protein filaments assembled from tubulin subunits, which play a key role for cell division. Ligands that target microtubules and affect their dynamics belong to the most successful classes of chemotherapeutic drugs against cancer by inhibiting cell proliferation. Here we have analyzed three structurally unrelat...
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Full title
new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
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Record Identifier
TN_cdi_pnas_primary_111_38_13817
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_38_13817
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1408124111
