Electrostatic transition state stabilization rather than reactant destabilization provides the chemi...
Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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For more than half a century, transition state theory has provided a useful framework for understanding the origins of enzyme catalysis. As proposed by Pauling, enzymes accelerate chemical reactions by binding transition states tighter than substrates, thereby lowering the activation energy compared with that of the corresponding uncatalyzed proces...
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Full title
Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis
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TN_cdi_pnas_primary_111_49_17516
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_49_17516
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1408512111
