G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA binding. The G overhang spontan...
Alternative Titles
Full title
G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_111_8_2990
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_8_2990
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1321436111
