Yeast homologous recombination-based promoter engineering for the activation of silent natural produ...
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory culture conditions. Silent gene clusters represent a promising resource for natural product discovery and the development of a new generation of therapeutics. Unfortunately, the characterizatio...
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Full title
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pnas_primary_112_29_8953
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_112_29_8953
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1507606112
