Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex
Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex
About this item
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Author / Creator
Ma, Yuanyuan , Wu, Lijie , Shaw, Neil , Gao, Yan , Wang, Jin , Sun, Yuna , Lou, Zhiyong , Yan, Liming , Zhang, Rongguang and Rao, Zihe
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for prevention of lethal mutagenesis, and the C-terminal domain functions as a (guanine-N7) methyl transferase (N7-MTase) for mRNA capping. The molecular basis of both t...
Alternative Titles
Full title
Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_112_30_9436
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_112_30_9436
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1508686112
