Biphasic regulation of InsP₃ receptor gating by dual Ca2+ release channel BH3-like domains mediates...
Biphasic regulation of InsP₃ receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Antiapoptotic Bcl-2 family members interact with inositol trisphosphate receptor (InsP₃R) Ca2+ release channels in the endoplasmic reticulum to modulate Ca2+ signals that affect cell viability. However, the molecular details and consequences of their interactions are unclear. Here, we found that Bcl-xL activates single InsP₃R channels with a biphas...
Alternative Titles
Full title
Biphasic regulation of InsP₃ receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_113_13_E1953
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_113_13_E1953
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1517935113
