Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer mod...
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
RNA-based cancer therapies are hindered by the lack of delivery vehicles that avoid cancer-induced organ dysfunction, which exacerbates carrier toxicity. We address this issue by reporting modular degradable dendrimers that achieve the required combination of high potency to tumors and low hepatotoxicity to provide a pronounced survival benefit in...
Alternative Titles
Full title
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
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Record Identifier
TN_cdi_pnas_primary_113_3_520
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_113_3_520
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1520756113
