Mutations of the ras Gene Product p21 That Abolish Guanine Nucleotide Binding
Mutations of the ras Gene Product p21 That Abolish Guanine Nucleotide Binding
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Washington, DC: National Academy of Sciences of the United States of America
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Language
English
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Washington, DC: National Academy of Sciences of the United States of America
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Contents
We have constructed several point mutations affecting the GTP-binding site of p21, the ras-encoded protein. Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities...
Alternative Titles
Full title
Mutations of the ras Gene Product p21 That Abolish Guanine Nucleotide Binding
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Record Identifier
TN_cdi_pnas_primary_83_14_5076
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_83_14_5076
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.83.14.5076
