Mitochondrial Mutational Spectra in Human Cells and Tissues
Mitochondrial Mutational Spectra in Human Cells and Tissues
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences of the United States of America
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More information
Scope and Contents
Contents
We have found that human organs such as colon, lung, and muscle, as well as their derived tumors, share nearly all mitochondrial hotspot point mutations. Seventeen hotspots, primarily G → A and A → G transitions, have been identified in the mitochondrial sequence of base pairs 10,030-10,130. Mutant fractions increase with the number of cell generat...
Alternative Titles
Full title
Mitochondrial Mutational Spectra in Human Cells and Tissues
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_94_25_13798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_94_25_13798
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.94.25.13798
