Sequence Motifs in Adenoviral DNA Block Immune Activation by Stimulatory CpG Motifs
Sequence Motifs in Adenoviral DNA Block Immune Activation by Stimulatory CpG Motifs
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Unmethylated CpG dinucleotides in particular base contexts (CpG-S motifs) are relatively common in bacterial DNA but are rare in vertebrate DNA. B cells and monocytes have the ability to detect such CpG-S motifs that trigger innate immune defenses with production of Th1-like cytokines. Despite comparable levels of unmethylated CpG dinucleotides, DN...
Alternative Titles
Full title
Sequence Motifs in Adenoviral DNA Block Immune Activation by Stimulatory CpG Motifs
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Record Identifier
TN_cdi_pnas_primary_95_21_12631_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_95_21_12631_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.95.21.12631
