Mice Mutant for Glucokinase Regulatory Protein Exhibit Decreased Liver Glucokinase: A Sequestration...
Mice Mutant for Glucokinase Regulatory Protein Exhibit Decreased Liver Glucokinase: A Sequestration Mechanism in Metabolic Regulation
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Contents
The importance of glucokinase (GK; EC 2.7.1.12) in glucose homeostasis has been demonstrated by the association of GK mutations with diabetes mellitus in humans and by alterations in glucose metabolism in transgenic and gene knockout mice. Liver GK activity in humans and rodents is allosterically inhibited by GK regulatory protein (GKRP). To furthe...
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Full title
Mice Mutant for Glucokinase Regulatory Protein Exhibit Decreased Liver Glucokinase: A Sequestration Mechanism in Metabolic Regulation
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TN_cdi_pnas_primary_96_25_14511_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_96_25_14511_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.25.14511
