Stepwise Unfolding of Titin under Force-Clamp Atomic Force Microscopy
Stepwise Unfolding of Titin under Force-Clamp Atomic Force Microscopy
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Here we demonstrate the implementation of a single-molecule force clamp adapted for use with an atomic force microscope. We show that under force-clamp conditions, an engineered titin protein elongates in steps because of the unfolding of its modules and that the waiting times to unfold are exponentially distributed. Force-clamp measurements direct...
Alternative Titles
Full title
Stepwise Unfolding of Titin under Force-Clamp Atomic Force Microscopy
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Record Identifier
TN_cdi_pnas_primary_98_2_468_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_98_2_468_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.98.2.468
