Presenilin-1 Binds Cytoplasmic Epithelial Cadherin, Inhibits Cadherin/p120 Association, and Regulate...
Presenilin-1 Binds Cytoplasmic Epithelial Cadherin, Inhibits Cadherin/p120 Association, and Regulates Stability and Function of the Cadherin/Catenin Adhesion Complex
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and requires the membrane-proximal cytoplasmic sequence 604-615 of mature E-cadherin. This sequence is also required for E-cadherin binding of protein p120...
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Full title
Presenilin-1 Binds Cytoplasmic Epithelial Cadherin, Inhibits Cadherin/p120 Association, and Regulates Stability and Function of the Cadherin/Catenin Adhesion Complex
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Record Identifier
TN_cdi_pnas_primary_98_5_2381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_98_5_2381
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.041603398
