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miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1009160928

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

About this item

Full title

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2011-12, Vol.17 (12), p.1627-1635

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

This report identifies a new contribution of members of the miR-200 family to tumorigenesis. miR-200a and miR-141 specifically regulate p38α, contributing to the cellular modulation of oxidative stress responses. In this role, the miRs can accelerate ovarian tumorigenesis but also endow cancer cells with increased sensitivity to ROS-inducing chemot...

Alternative Titles

Full title

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1009160928

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1009160928

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/nm.2512

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