A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation
A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation
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Author / Creator
Bergamini, Giovanna , Bell, Kathryn , Shimamura, Satoko , Werner, Thilo , Cansfield, Andrew , Müller, Katrin , Perrin, Jessica , Rau, Christina , Ellard, Katie , Hopf, Carsten , Doce, Carola , Leggate, Daniel , Mangano, Raffaella , Mathieson, Toby , O'mahony, Alison , Plavec, Ivan , Rharbaoui, Faiza , Reinhard, Friedrich , Savitski, Mikhail M , Ramsden, Nigel , Hirsch, Emilio , Drewes, Gerard , Rausch, Oliver , Bantscheff, Marcus and Neubauer, Gitte
Publisher
Cambridge: Nature Publishing Group
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Language
English
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Publisher
Cambridge: Nature Publishing Group
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Contents
We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC24832, which is to our knowledge the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and i...
Alternative Titles
Full title
A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation
Authors, Artists and Contributors
Author / Creator
Bell, Kathryn
Shimamura, Satoko
Werner, Thilo
Cansfield, Andrew
Müller, Katrin
Perrin, Jessica
Rau, Christina
Ellard, Katie
Hopf, Carsten
Doce, Carola
Leggate, Daniel
Mangano, Raffaella
Mathieson, Toby
O'mahony, Alison
Plavec, Ivan
Rharbaoui, Faiza
Reinhard, Friedrich
Savitski, Mikhail M
Ramsden, Nigel
Hirsch, Emilio
Drewes, Gerard
Rausch, Oliver
Bantscheff, Marcus
Neubauer, Gitte
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1018708241
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1018708241
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.957
