Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
BMP7 has been previously shown to protect against renal fibrosis. Raghu Kalluri and his colleagues have now identified activin-like kinase 3 (Alk3) as the key co-receptor for BMP7 in the kidney and have identified an orally available, small-peptide agonist of Alk3 that reduces established fibrosis in five animal models of kidney injury.
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Full title
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
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TN_cdi_proquest_journals_1018980917
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1018980917
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2629
