Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells vi...
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The authors uncover a role for the tyrosine phosphatase SHP2 in the propagation and maintenance of breast cancer tumor initiating cells. This role of SHP2 contributes to the growth and metastasis of tumors
in vivo
and is mediated by a newly uncovered downstream pathway that, through regulation of ERK, modulates the activity of transcription f...
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Full title
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
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TN_cdi_proquest_journals_1019004043
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1019004043
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2645
