Mitochondrial injury and apoptosis promote organ failure after ischemic acute kidney injury (AKI), a common cause of morbidity and mortality. In these studies, we propose that hexokinase (HK), mitofusin 2 (MFN2) and Bax, key mitochondrial associated proteins, modulate apoptotic cell death and organ function after ischemia. In the kidney, HKI and HK...

Hexokinase and mitofusin 2: Mitochondrial modulators of apoptosis in ischemic acute kidney injury