Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is atte...
Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity
About this item
Full title
Author / Creator
Zak, Daniel E , Andersen-Nissen, Erica , Peterson, Eric R , Sato, Alicia , Hamilton, M. Kristina , Borgerding, Joleen , Krishnamurty, Akshay T , Chang, Joanne T , Adams, Devin J , Hensley, Tiffany R , Salter, Alexander I , Morgan, Cecilia A , Duerr, Ann C , De Rosa, Stephen C , Aderem, Alan and McElrath, M. Juliana
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
To better understand how innate immune responses to vaccination can lead to lasting protective immunity, we used a systems approach to define immune signatures in humans over 1 wk following MRKAd5/HIV vaccination that predicted subsequent HIV-specific T-cell responses. Within 24 h, striking increases in peripheral blood mononuclear cell gene expres...
Alternative Titles
Full title
Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1238251232
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1238251232
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1208972109
