Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Cons...
Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex: e1002065
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San Francisco: Public Library of Science
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Language
English
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San Francisco: Public Library of Science
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Contents
Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male reproductive diseases. Despite widespread effects of P...
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Full title
Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex: e1002065
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TN_cdi_proquest_journals_1313552806
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1313552806
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ISSN
1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002065
