Targeting PI3K/Akt represses Hypoxia inducible factor-1[alpha] activation and sensitizes Rhabdomyosa...
Targeting PI3K/Akt represses Hypoxia inducible factor-1[alpha] activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Hypoxia inducible factor-1 [alpha] (HIF-1[alpha]) has been identified as an important novel target in apoptosis resistance of pediatric tumors such as Rhabdomyosarcoma (RMS) and Ewing's sarcoma (ES). Evidence suggests that PI3K/Akt signaling plays a role in regulation of HIF-1[alpha] activation as well as apoptosis resistance in various...
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Targeting PI3K/Akt represses Hypoxia inducible factor-1[alpha] activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis
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TN_cdi_proquest_journals_1347003578
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1347003578
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E-ISSN
1475-2867
DOI
10.1186/1475-2867-13-36
