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Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1349832359

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

About this item

Full title

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7684-7689

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass spectrometry technology. The results show that folding proceeds through distinct intermediates in a stepwise pathway that sequentially incorporates cooperative native-like structural elements to build the...

Alternative Titles

Full title

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1349832359

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1349832359

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1305887110

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