Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry
Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass spectrometry technology. The results show that folding proceeds through distinct intermediates in a stepwise pathway that sequentially incorporates cooperative native-like structural elements to build the...
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Full title
Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry
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TN_cdi_proquest_journals_1349832359
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1349832359
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1305887110