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Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated...

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1349832667

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

About this item

Full title

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7862-7867

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Volunteers immunized under chloroquine chemoprophylaxis with Plasmodium falciparum sporozoites (CPS) develop complete, long-lasting protection against homologous sporozoite challenge. Chloroquine affects neither sporozoites nor liver-stages, but kills only asexual forms in erythrocytes once released from the liver into the circulation. Consequently...

Alternative Titles

Full title

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1349832667

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1349832667

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1220360110

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