A liver Hif-2[alpha]-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhi...
A liver Hif-2[alpha]-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
About this item
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Author / Creator
Wei, Kevin , Piecewicz, Stephanie M , Mcginnis, Lisa M , Taniguchi, Cullen M , Wiegand, Stanley J , Anderson, Keith , Chan, Carol W-m , Mulligan, Kimberly X , Kuo, David , Yuan, Jenny , Vallon, Mario , Morton, Lori C , Lefai, Etienne , Simon, M Celeste , Maher, Jacquelyn J , Mithieux, Gilles , Rajas, Fabienne , Annes, Justin P , Mcguinness, Owen P , Thurston, Gavin , Giaccia, Amato J and Kuo, Calvin J
Publisher
New York: Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group
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More information
Scope and Contents
Contents
Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synthesis and lipogenesis. The liver possesses a rich sinusoidal capillary network with a higher degree of hypoxia and lower gluconeogenesis in the perivenous zone as compared to the rest of the organ. Here, we show that diverse vasc...
Alternative Titles
Full title
A liver Hif-2[alpha]-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
Authors, Artists and Contributors
Author / Creator
Piecewicz, Stephanie M
Mcginnis, Lisa M
Taniguchi, Cullen M
Wiegand, Stanley J
Anderson, Keith
Chan, Carol W-m
Mulligan, Kimberly X
Kuo, David
Yuan, Jenny
Vallon, Mario
Morton, Lori C
Lefai, Etienne
Simon, M Celeste
Maher, Jacquelyn J
Mithieux, Gilles
Rajas, Fabienne
Annes, Justin P
Mcguinness, Owen P
Thurston, Gavin
Giaccia, Amato J
Kuo, Calvin J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1440074532
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1440074532
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3295
