Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
CaMKII is known to be pathologically activated in heart failure and arrhythmias; here it is shown that glucose-induced CaMKII activation via
O
-linked glycosylation might contribute to cardiac pathology in diabetes.
Link between glucose and arrhythmia
During heart failure the enzyme Ca
2+
/calmodulin-dependent protein kinase II (C...
Alternative Titles
Full title
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
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TN_cdi_proquest_journals_1448807730
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1448807730
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12537
