TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing
TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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This study shows that TMEM16C facilitates Slack potassium channel activity in the dorsal root ganglia in rats. By generating a gene knockout rat and using electrophysiology, the authors show that TMEM16C modulates mechanical and thermal pain processing by associating with Slack to enhance sodium-activated potassium channel activity.
TMEM16C belo...
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Full title
TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing
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TN_cdi_proquest_journals_1459386232
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1459386232
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3468
