A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients...
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
About this item
Full title
Author / Creator
Horsley, Laura , Cummings, Jeff , Middleton, Mark , Ward, Tim , Backen, Alison , Clamp, Andrew , Dawson, Martin , Farmer, Hayley , Fisher, Nita , Halbert, Gavin , Halford, Sarah , Harris, Adrian , Hasan, Jurjees , Hogg, Philip , Kumaran, Gireesh , Little, Ross , Parker, Geoff J. M. , Potter, Paula , Saunders, Mark , Roberts, Caleb , Shaw, Danielle , Smith, Nigel , Smythe, Jon , Taylor, Andrew , Turner, Helen , Watson, Yvonne , Dive, Caroline , Jayson, Gordon C. , A Cancer Research UK Drug Development Office Phase I clinical trial and Cancer Research UK Drug Development Office Phase I clinical trial
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Background
4-(
N
-(
S
-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is a water-soluble mitochondrial toxin that binds to adenine nucleotide translocase in the inner mitochondrial membrane, thereby targeting cell proliferation. This phase 1 study investigated safety, dose-limiting toxicities (DLTs), maximum tolerated dose (MTD) a...
Alternative Titles
Full title
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
Authors, Artists and Contributors
Author / Creator
Cummings, Jeff
Middleton, Mark
Ward, Tim
Backen, Alison
Clamp, Andrew
Dawson, Martin
Farmer, Hayley
Fisher, Nita
Halbert, Gavin
Halford, Sarah
Harris, Adrian
Hasan, Jurjees
Hogg, Philip
Kumaran, Gireesh
Little, Ross
Parker, Geoff J. M.
Potter, Paula
Saunders, Mark
Roberts, Caleb
Shaw, Danielle
Smith, Nigel
Smythe, Jon
Taylor, Andrew
Turner, Helen
Watson, Yvonne
Dive, Caroline
Jayson, Gordon C.
A Cancer Research UK Drug Development Office Phase I clinical trial
Cancer Research UK Drug Development Office Phase I clinical trial
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1459530984
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1459530984
Other Identifiers
ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-013-2320-9
