Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
About this item
Full title
Author / Creator
Xie, Yang , Zamponi, Raffaella , Charlat, Olga , Ramones, Melissa , Swalley, Susanne , Jiang, Xiaomo , Rivera, Daniel , Tschantz, William , Lu, Bo , Quinn, Lisa , Dimitri, Chris , Parker, Jefferson , Jeffery, Doug , Wilcox, Sheri K , Watrobka, Mike , LeMotte, Peter , Granda, Brian , Porter, Jeffrey A , Myer, Vic E , Loew, Andreas and Cong, Feng
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Subjects
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Scope and Contents
Contents
R‐spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have been proposed as potential receptors of R‐spondin, including LGR4/5, membrane E3 ubiquitin ligases ZNRF3/RNF43 and several others proteins. Here, we show that R‐spondin interacts with ZNRF3/RNF43 and LGR4 through distinct...
Alternative Titles
Full title
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Authors, Artists and Contributors
Author / Creator
Zamponi, Raffaella
Charlat, Olga
Ramones, Melissa
Swalley, Susanne
Jiang, Xiaomo
Rivera, Daniel
Tschantz, William
Lu, Bo
Quinn, Lisa
Dimitri, Chris
Parker, Jefferson
Jeffery, Doug
Wilcox, Sheri K
Watrobka, Mike
LeMotte, Peter
Granda, Brian
Porter, Jeffrey A
Myer, Vic E
Loew, Andreas
Cong, Feng
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1462391677
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1462391677
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2013.167
