von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin [alpha]IIb[Beta]3
von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin [alpha]IIb[Beta]3
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Publisher
Ann Arbor: American Society for Clinical Investigation
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Language
English
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Publisher
Ann Arbor: American Society for Clinical Investigation
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Contents
von Willebrand disease type 2B (vWD-type 2B) is characterized by gain-of-function mutations in von Willebrand factor (vWF) that enhance its binding to the glycoprotein Ib-IX-V complex on platelets. Patients with vWD-type 2B have a bleeding tendency that is linked to loss of vWF multimers and/or thrombocytopenia. In this study, we uncovered evidence...
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Full title
von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin [alpha]IIb[Beta]3
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TN_cdi_proquest_journals_1468872688
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1468872688
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ISSN
0021-9738
E-ISSN
1558-8238
