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MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1471917847

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

About this item

Full title

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

Publisher

Washington, DC: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (51), p.20783-20788

Language

English

Formats

Publication information

Publisher

Washington, DC: National Academy of Sciences

More information

Scope and Contents

Contents

Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is caused by antibodies against postsynaptic proteins, including (i) acetylcholine receptors, the neurotransmitter receptor, (ii) muscle-specific kinase (MuSK), a receptor tyrosine k...

Alternative Titles

Full title

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1471917847

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1471917847

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1313944110

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