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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiot...

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiot...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1497039655

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

About this item

Full title

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (5), p.1957-1962

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Recent developments in next-generation sequencing technologies have brought recognition of microbial genomes as a rich resource for novel natural product discovery. However, owing to the scarcity of efficient procedures to connect genes to molecules, only a small fraction of secondary metabolomes have been investigated to date. Transformation-assoc...

Alternative Titles

Full title

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1497039655

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1497039655

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1319584111

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