An activin receptor IIA ligand trap corrects ineffective erythropoiesis in [beta]-thalassemia
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in [beta]-thalassemia
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Author / Creator
Dussiot, Michael , Maciel, Thiago T , Fricot, Aurélie , Chartier, Céline , Negre, Olivier , Veiga, Joel , Grapton, Damien , Paubelle, Etienne , Payen, Emmanuel , Beuzard, Yves , Leboulch, Philippe , Ribeil, Jean-antoine , Arlet, Jean-benoit , Coté, Francine , Courtois, Geneviève , Ginzburg, Yelena Z , Daniel, Thomas O , Chopra, Rajesh , Sung, Victoria , Hermine, Olivier and Moura, Ivan C
Publisher
New York: Nature Publishing Group
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Language
English
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Publisher
New York: Nature Publishing Group
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Contents
The pathophysiology of ineffective erythropoiesis in [beta]-thalassemia is poorly understood. We report that RAP-011, an activin receptor IIA (ActRIIA) ligand trap, improved ineffective erythropoiesis, corrected anemia and limited iron overload in a mouse model of [beta]-thalassemia intermedia. Expression of growth differentiation factor 11 (GDF11)...
Alternative Titles
Full title
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in [beta]-thalassemia
Authors, Artists and Contributors
Author / Creator
Maciel, Thiago T
Fricot, Aurélie
Chartier, Céline
Negre, Olivier
Veiga, Joel
Grapton, Damien
Paubelle, Etienne
Payen, Emmanuel
Beuzard, Yves
Leboulch, Philippe
Ribeil, Jean-antoine
Arlet, Jean-benoit
Coté, Francine
Courtois, Geneviève
Ginzburg, Yelena Z
Daniel, Thomas O
Chopra, Rajesh
Sung, Victoria
Hermine, Olivier
Moura, Ivan C
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Record Identifier
TN_cdi_proquest_journals_1513816294
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1513816294
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3468
