Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of [sigma]1 Recep...
Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of [sigma]1 Receptors in the Brain
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Basel: MDPI AG
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English
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Basel: MDPI AG
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Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu2SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity. The additional hydroxy moiety in the 4-position was exploited for the introduction of various substituents. Willia...
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Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of [sigma]1 Receptors in the Brain
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TN_cdi_proquest_journals_1525784530
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1525784530
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1424-8247
DOI
10.3390/ph7010078
