Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Nove...
Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru([eta]6-p-phenylethacrynate)Cl2(pta)]
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Basel: MDPI AG
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English
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Basel: MDPI AG
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The ruthenium-based complex [Ru(η6-p-phenylethacrynate)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane), termed ethaRAPTA, is an interesting antitumor compound. The elucidation of the molecular mechanism of drug activity is central to the drug development program. To this end, we have characterized the ethaRAPTA interaction with DNA...
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Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru([eta]6-p-phenylethacrynate)Cl2(pta)]
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TN_cdi_proquest_journals_1526012253
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1526012253
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ISSN
1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms131013183
