Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 syste...
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cancer-related human chromosomal translocations are generated through the illegitimate joining of two non-homologous chromosomes affected by double-strand breaks (DSB). Effective methodologies to reproduce precise reciprocal tumour-associated chromosomal translocations are required to gain insight into the initiation of leukaemia and sarcomas. Here...
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Full title
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
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TN_cdi_proquest_journals_1531469539
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1531469539
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms4964
