Off-Target Effect ofdoublecortinFamily shRNA on Neuronal Migration Associated with Endogenous MicroR...
Off-Target Effect ofdoublecortinFamily shRNA on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation
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Cambridge: Elsevier Limited
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English
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Cambridge: Elsevier Limited
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Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example,doublecortin(Dcx) knockdown but not knockout shows a neocortical neuronal migration phenotype. H...
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Off-Target Effect ofdoublecortinFamily shRNA on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation
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TN_cdi_proquest_journals_1537379465
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1537379465
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ISSN
0896-6273
E-ISSN
1097-4199
DOI
10.1016/j.neuron.2014.04.036
