Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leuk...
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
About this item
Full title
Author / Creator
Sashida, Goro , Harada, Hironori , Matsui, Hirotaka , Oshima, Motohiko , Yui, Makiko , Harada, Yuka , Tanaka, Satomi , Mochizuki-Kashio, Makiko , Wang, Changshan , Saraya, Atsunori , Muto, Tomoya , Hayashi, Yoshihiro , Suzuki, Kotaro , Nakajima, Hiroshi , Inaba, Toshiya , Koseki, Haruhiko , Huang, Gang , Kitamura, Toshio and Iwama, Atsushi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Loss-of-function mutations of
EZH2
, a catalytic component of polycomb repressive complex 2 (PRC2), are observed in ~\n10% of patients with myelodysplastic syndrome (MDS), but are rare in acute myeloid leukaemia (AML). Recent studies have shown that
EZH2
mutations are often associated with
RUNX1
mutations in MDS patients, although...
Alternative Titles
Full title
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
Authors, Artists and Contributors
Author / Creator
Harada, Hironori
Matsui, Hirotaka
Oshima, Motohiko
Yui, Makiko
Harada, Yuka
Tanaka, Satomi
Mochizuki-Kashio, Makiko
Wang, Changshan
Saraya, Atsunori
Muto, Tomoya
Hayashi, Yoshihiro
Suzuki, Kotaro
Nakajima, Hiroshi
Inaba, Toshiya
Koseki, Haruhiko
Huang, Gang
Kitamura, Toshio
Iwama, Atsushi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1539264403
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1539264403
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5177
