Up-regulation of glycolytic metabolism is required for HIF1[alpha]-driven bone formation
Up-regulation of glycolytic metabolism is required for HIF1[alpha]-driven bone formation
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Washington: National Academy of Sciences
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Language
English
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Washington: National Academy of Sciences
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The bone marrow environment is among the most hypoxic in the body, but how hypoxia affects bone formation is not known. Because low oxygen tension stabilizes hypoxia-inducible factor alpha (HIFα) proteins, we have investigated the effect of expressing a stabilized form of HIF1a in osteoblast precursors. Brief stabilization of HIF1α in SP7-positive...
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Full title
Up-regulation of glycolytic metabolism is required for HIF1[alpha]-driven bone formation
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TN_cdi_proquest_journals_1539404138
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1539404138
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ISSN
0027-8424
E-ISSN
1091-6490
