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The Ca^sup 2+^-calmodulin-Ca^sup 2+^/calmodulin-dependent protein kinase II signaling pathway is inv...

The Ca^sup 2+^-calmodulin-Ca^sup 2+^/calmodulin-dependent protein kinase II signaling pathway is inv...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1553045247

The Ca^sup 2+^-calmodulin-Ca^sup 2+^/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

About this item

Full title

The Ca^sup 2+^-calmodulin-Ca^sup 2+^/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

Publisher

Heidelberg: Springer Nature B.V

Journal title

Archives of toxicology, 2014-09, Vol.88 (9), p.1695

Language

English

Formats

Publication information

Publisher

Heidelberg: Springer Nature B.V

More information

Scope and Contents

Contents

Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca^sup 2+^ increase plays a permissive role in these events, but the underlying mechanisms are poorly known. We examined in...

Alternative Titles

Full title

The Ca^sup 2+^-calmodulin-Ca^sup 2+^/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1553045247

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1553045247

Other Identifiers

ISSN

0340-5761

E-ISSN

1432-0738

DOI

10.1007/s00204-014-1219-5

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