Peptide-siRNA nanocomplexes targeting NF-[kappa]B subunit p65 suppress nascent experimental arthriti...
Peptide-siRNA nanocomplexes targeting NF-[kappa]B subunit p65 suppress nascent experimental arthritis
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Ann Arbor: American Society for Clinical Investigation
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English
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Ann Arbor: American Society for Clinical Investigation
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In this paper, the authors demonstrated that a melittin-derived cationic amphipathic peptide combined with siRNA targeting the p65 subunit of NF-κB (p5RHH-p65) noncovalently self-assemble into stable nanocomplexes that home to the inflamed joints in a murine model of RA. Specifically, administration of p5RHH-p65 siRNA nanocomplexes abrogated inflam...
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Peptide-siRNA nanocomplexes targeting NF-[kappa]B subunit p65 suppress nascent experimental arthritis
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TN_cdi_proquest_journals_1614373453
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1614373453
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ISSN
0021-9738
E-ISSN
1558-8238
