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HSP70 sequestration by free [alpha]-globin promotes ineffective erythropoiesis in [Beta]-thalassaemi...

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HSP70 sequestration by free [alpha]-globin promotes ineffective erythropoiesis in [Beta]-thalassaemi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1614660123

HSP70 sequestration by free [alpha]-globin promotes ineffective erythropoiesis in [Beta]-thalassaemia

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London: Nature Publishing Group

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Contents

β-Thalassaemia major (β-TM) is an inherited haemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of haemoglobin, leading to the accumulation of free α-globin chains that form toxic aggregates. Despite extensive knowledge of the molecular defects causing β-TM, little is known of the mechanisms responsible for the ine...

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Full title

HSP70 sequestration by free [alpha]-globin promotes ineffective erythropoiesis in [Beta]-thalassaemia

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Record Identifier

TN_cdi_proquest_journals_1614660123

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1614660123

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ISSN

0028-0836

E-ISSN

1476-4687

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