Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells
Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells
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Author / Creator
Li, Jie , Jia, Shang and Chen, Peng R
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Diels-Alder chemistry is widely used for bioconjugations, and one variant of the reaction can ‘deprotect’ a small molecule via spontaneous elimination. This activation chemistry is now demonstrated on biomolecules in cells at high yields in 10 minutes.
Small molecules that specifically activate an intracellular protein of interest are highly des...
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Full title
Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells
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TN_cdi_proquest_journals_1647096887
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1647096887
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1656
