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PTP[sigma] functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential fo...

PTP[sigma] functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential fo...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1656033260

PTP[sigma] functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

About this item

Full title

PTP[sigma] functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (6), p.1874

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Leukocyte common antigen-related receptor protein tyrosine phosphatases -- comprising LAR, PTPd, and PTP... -- are synaptic adhesion molecules that organize synapse development. Here, we identify glypican 4 (GPC-4) as a ligand for PTP... GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of P...

Alternative Titles

Full title

PTP[sigma] functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1656033260

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1656033260

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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