Dual agonist occupancy of AT1-R-[alpha]2C-AR heterodimers results in atypical Gs-PKA signaling
Dual agonist occupancy of AT1-R-[alpha]2C-AR heterodimers results in atypical Gs-PKA signaling
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Bellot, Morgane , Galandrin, Ségolène , Boularan, Cédric , Matthies, Heinrich J , Despas, Fabien , Denis, Colette , Javitch, Jonathan , Mazères, Serge , Sanni, Samra Joke , Pons, Véronique , Seguelas, Marie-hélène , Hansen, Jakob L , Pathak, Atul , Galli, Aurelio , Sénard, Jean-michel and Galés, Céline
Publisher
Cambridge: Nature Publishing Group
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English
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Cambridge: Nature Publishing Group
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Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major prevalent cardiovascular diseases that contribute to cardiac pathophysiology and morbidity. Herein, we explore whether heterodimerization of presynaptic AngII AT1 receptor (AT1-R) and NE α2C -adrenergic receptor (α2C -AR) could underlie their functional cross-ta...
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Full title
Dual agonist occupancy of AT1-R-[alpha]2C-AR heterodimers results in atypical Gs-PKA signaling
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TN_cdi_proquest_journals_1667698388
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1667698388
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1766
