SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
About this item
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Author / Creator
Kim, Dohoon , Fiske, Brian P. , Birsoy, Kivanc , Freinkman, Elizaveta , Kami, Kenjiro , Possemato, Richard L. , Chudnovsky, Yakov , Pacold, Michael E. , Chen, Walter W. , Cantor, Jason R. , Shelton, Laura M. , Gui, Dan Y. , Kwon, Manjae , Ramkissoon, Shakti H. , Ligon, Keith L. , Kang, Seong Woo , Snuderl, Matija , Vander Heiden, Matthew G. and Sabatini, David M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Tumours are a low-oxygen environment, in this study glioblastoma cells are found to overexpress the serine hydroxymethyltransferase SHMT2; SHMT acts to reduce oxygen consumption, which confers the tumour cells with a survival advantage.
Low oxygen gives tumour cells an edge
Tumour cells thrive in a low-oxygen environment, and in this study Da...
Alternative Titles
Full title
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Authors, Artists and Contributors
Author / Creator
Fiske, Brian P.
Birsoy, Kivanc
Freinkman, Elizaveta
Kami, Kenjiro
Possemato, Richard L.
Chudnovsky, Yakov
Pacold, Michael E.
Chen, Walter W.
Cantor, Jason R.
Shelton, Laura M.
Gui, Dan Y.
Kwon, Manjae
Ramkissoon, Shakti H.
Ligon, Keith L.
Kang, Seong Woo
Snuderl, Matija
Vander Heiden, Matthew G.
Sabatini, David M.
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1674426660
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1674426660
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14363
