Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires...
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the C H2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors. Sialy...
Alternative Titles
Full title
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs
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TN_cdi_proquest_journals_1682906920
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1682906920
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1505292112
