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Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, includin...

Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, includin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1712457383

Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, including breast cancer

About this item

Full title

Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, including breast cancer

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Cancer chemotherapy and pharmacology, 2015-10, Vol.76 (4), p.739-750

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Purpose
This phase I trial assessed afatinib, an irreversible ErbB family blocker, plus vinorelbine in Japanese patients with advanced solid tumors not amenable to standard treatment.
Methods
Primary objectives were evaluation of safety and the maximum tolerated dose (MTD) of once-daily (QD) afatinib plus weekly intravenous vinorelbine. Se...

Alternative Titles

Full title

Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, including breast cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1712457383

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1712457383

Other Identifiers

ISSN

0344-5704

E-ISSN

1432-0843

DOI

10.1007/s00280-015-2826-4

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